Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase.
نویسندگان
چکیده
منابع مشابه
Molecular Evolution of Threonine Dehydratase in Bacteria
Threonine dehydratase converts L-threonine to 2-ketobutyrate. Several threonine dehydratases exist in bacteria, but their origins and evolutionary pathway are unknown. Here we analyzed all the available threonine dehydratases in bacteria and proposed an evolutionary pathway leading to the genes encoding three different threonine dehydratases CTD, BTD1 and BTD2. The ancestral threonine dehydrata...
متن کاملBiodegradative Threonine Dehydratase by Glyoxylate"
A timeand concentration-dependent irreversible inactivation of the Escherichia coli biodegradative threonine dehydratase by glyoxylate is accompanied by enzyme aggregation, apparent covalent binding of 4 mol of glyoxylate/mol of aggregated species, and a displacement of the absorption maximum of the enzyme-bound pyridoxal phosphate from 413 to 388 nm (Park, L. S., and Datta, P. (1979) J Biol. C...
متن کاملModeling of the Effects of Threonine, Valine, Isoleucine and Pyridoxal 5'-monophosphate on Biosynthetic Threonine Dehydratase Reaction
Motivation: Development of mathematical models that adequately describe moleculargenetic mechanisms is one of the main tasks in modern bioinformatics. Not only should a model be sensitive to the particulars of enzyme reactions underlying cell life activity, but also to regulation exerted on enzyme activity by metabolites and specialized cell proteins. Results: The gene network for branched-chai...
متن کاملIsolation and Properties of a Homogeneous Preparation of Cystathionine Synthetase-l-serine and L-threonine Dehydratase.
Selim and Greenberg (1, 2) achieved a considerable degree of purification of L-serine dehydratase (L-serine hydro-lyase (deaminating), EC 4.2.1.13) from rat liver and demonstrated that this protein preparation contained the cystathionine-synthesizing activity of the liver (L-serine hydro-lyase (adding L-homocysteine), EC 4.2.1.21). These workers (2) also observed activity of their enzyme prepar...
متن کاملThe separation of rat liver serine dehydratase and cystathionine synthase.
A compound derived from pyruvic acid and homocysteine has been isolated from reaction mixtures containing serinel*C, homocysteine, and serine dehydratase preparations. The formation of this product interferes with commonly used assays of serine dehydratase, which are based on the serine, pyruvic acid, or homocysteine content of incubation mixtures. Improved assay procedures have permitted the i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1986
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1986.tb04600.x